Cell Signaling: Flight or Fight pathway

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Developed by: Donna Koslowsky

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Cell Signaling: Fight or Flight Response

Campbell's Biology, 9th ed. Chapter 11

***Note: In this course, chapter 11 is taught after chapters 16-18 which cover DNA replication, transcription, translation, and regulation of gene expression.***

Connection to Vision and Change

Core Concepts

3. INFORMATION FLOW, EXCHANGE , AND STORAGE :

The growth and behavior of organisms are activated through the expression of genetic information in context.

Core Competencies and Disciplinary Practice

3. ABILITY TO USE MODELING AND SIMULATION

Biology focuses on the study of complex systems.

Objectives

  • Identify basic signal transduction components in a model for control a basic metabolic response.
  • Based on the model, explain how different signals impact metabolism.
  • Identify the major steps in this cell signaling pathway.

Description

At the beginning of class, students are given a diagram depicting how adrenaline drives changes in two metabolic enzymes.  A brief (5-10 minute) mini-lecture is given on key aspects of signal transduction. The students then answer clicker questions asking them to both interpret the diagram and predict how a variety of changes in the pathway would impact metabolism.

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Handout for students to view epinephrine signaling pathway204.04 KB
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Slides and clicker questions for epinephrine signaling activity ONLY2.58 MB
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Full lecture including activity and clicker slides4.08 MB

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This material is based upon work supported by the National Science Foundation (DUE grants: 1438739, 1323162, 1347740, 0736952 and 1022653). Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF.